Two-stage biomarker panel study and estimation allowing early termination for futility
نویسندگان
چکیده
منابع مشابه
Conditional estimation after a two-stage diagnostic biomarker study that allows early termination for futility.
Many biomarkers identified in marker discovery are shown to have inadequate performance in validation studies. This motivates the use of group sequential designs that allow early termination for futility. However, an option for early termination will lead to biased estimates for studies that reach full enrollment. We propose conditional estimators and confidence intervals that correct for this ...
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ژورنال
عنوان ژورنال: Biostatistics
سال: 2015
ISSN: 1465-4644,1468-4357
DOI: 10.1093/biostatistics/kxv017